The Rock Island Line was in operation from 1852 to 1980 and ran west and south west from Chicago. For many years it was a US Class I railroad, but one of the weaker roads. Its prospects might have been the brightest at the time of the cancel below:
C. R. I. & P. RY. CO.
A check made out the the Baltimore & Ohio Railroad to pay for forwarding freight charges, presumably for cargo heading east of Chicago.
Rock Island route map